SPS3 Publications Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. Posted: Mar 11th, 2015 Achieved blood pressures in the secondary prevention of small subcortical strokes (SPS3) study: challenges and lessons learned. Posted: Mar 11th, 2015 The Secondary Prevention of Small Subcortical Strokes (SPS3) study. Posted: Feb 27th, 2015