CHARGE: Cohorts for Heart and Aging Research in Genomic Epidemiology
The CHARGE consortium was formed to facilitate genome-wide association study (GWAS) meta-analyses and replication opportunities among large population-based cohort studies. The CHARGE consortium has expanded from the five original prospective cohort studies from the US and Europe to ten and coordinates the efforts of more than 40 working groups, including a working group on pharmacogenetics. The consortium aims to identify genetic determinants of risk factors, subclinical-disease measures, and clinical events. A genome-wide association study of blood pressure identified sixteen novel loci, ten of which provide new clues to blood pressure physiology. Findings so far provide new insights into the genetics and biology of blood pressure.