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ACEi-SS: Pharmacogenomics of ACE inhibitors in Sardinia

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After a run-in period of 8 weeks under standardized dietary regimen and complete diagnostic workout to confirm the presence of the disease and to exclude secondary hypertension, BP response to Ramipril 5mg/day was evaluated after 4 and 8 weeks of treatment: side effects were recorded. All patients were never treated mild-to-moderate essential hypertensive younger than 60 years and without any concurrent disease. A cohort of 411 patients was studied.

Long term follow-up: ongoing.

Cardiac (ECHO), renal, metabolic phenotypes available.

Serum, plasma, and urine samples are available.

The primary CV outcome was combined CV/cerebrovascular events while secondary outcomes were atrial fibrillation, CKD, new onset of diabetes.