IDEAL: Identification of the Determinants of the Efficacy of Arterial Blood Pressure Lowering Drugs
IDEAL was a crossover, double-blind, placebo-controlled trial that aimed to identify phenotypic, genetic, or environmental markers of BP response to ACEIs and diuretics in 112 white French participants. Mild hypertensive participants were aged 25-70 with no previous treatment of hypertension and received successively in a random order Indapamide 1.5 mg and Perindopril 8 mg for 4 weeks each, during periods separated by 4 weeks of placebo. Clinic/ office BP was taken after each 4 week regimen. Glucose, total cholesterol, LDL, HDL, TG, uric acid, potassium, sodium, creatinine, plasma renin activity, aldosterone, and CRP are available from baseline and creatinine, plasma renin activity, aldosterone, and CRP are available from follow up. Results are expected to improve knowledge in drug’s mechanisms and pathophysiology of hypertension in order to personalize treatment.