The Estonian biobank cohort participants represent a large proportion of the Estonian adult population (5%), making it ideal for population-based studies. Baseline health examinations, blood samples, white blood cells, and plasma tests, as well as a questionnaire on health-related topics are available. A significant portion of the cohort has whole genome sequencing, SNP data, and/or NMR metabolome data available. The data is continuously updated and some participants have been re-contacted for follow-up purposes and resampling. The Estonian Genome Center of the University of Tartu is actively collaborating with other universities and research institutes and encourages fellow scientists worldwide to co-initiate new projects.